Long-term intake of Lilium lancifolium mitigated osteoarthritic effects by suppressing inflammatory cytokines in a dog model

Long-term intake of Lilium lancifolium mitigated osteoarthritic effects by suppressing inflammatory cytokines in a dog model

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Background and Aim: Osteoarthritis (OA) is a chronic, painful, degenerative inflammatory disease of the synovial joints.Regular use of nonsteroidal anti-inflammatory drugs to decrease OA pain can have severe side effects, such as gastric irritation, ulcers, Medical and Ambulatory supplies / Incontinence and heart problems.Natural products are extensively used to minimize OA-associated pain and inflammatory reactions.Lilium lancifolium is commonly used to alleviate several diseases through its anti-inflammatory effects.This study examined the impact of L.

lancifolium extract on alleviating pain and inflammation associated with articular cartilage damage.Materials and Methods: Hydro-ethanol extracts of the L.lancifolium bulb were used.The experimental animals (adult beagle dogs) were divided into four groups: sham, which received neither treatment nor surgery; placebo, which received an empty gelatin capsule; glucosamine, which received glutamine (60 mg/kg); and L.lancifolium, which received an L.

lancifolium extract-filled (60 mg/kg) gelatin capsule for 8 weeks.OA was induced by an expert orthopedic surgeon in 2-year-old dogs through resection of cranial cruciate ligament and lateral collateral ligament.Inflammatory cytokines, enzymes, lameness score, radiology, and histological changes were assessed.Results: Our experiments showed that long-term oral therapy with Transmission L.lancifolium alleviated inflammation and increased histological damage.

L.lancifolium treatment effectively reduced cytokines, such as interleukin-6, metalloproteinase-9, leukotriene-4, prostaglandin, and cyclo-oxygenase in dogs with OA, suggesting the potential to minimize inflammatory reactions in OA.L.lancifolium showed anti-inflammatory qualities in dogs with OA.This effect was comparable with that of glucosamine OA treatment.

Conclusion: L.lancifolium supplementation represents a possible therapeutic and management option in this model of OA.